Immunohistochemical Expression of BCl2 Oncoprotein in Varying Histological Grades of Oral Squamous Cell Carcinoma

Immunohistochemical Expression of BCl2 Oncoprotein in Varying Histological Grades of Oral Squamous Cell Carcinoma

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Oral cancer has been rising in alarming numbers in the world which is anticipated to escalate at 70% by 2030.Although a lot of factors are responsible for the disease, genetics, and gene mutations play a major role in uncontrolled proliferation.Another major factor is apoptosis which is programmed cell death.

Apoptosis generally happens ps5 price new jersey in two pathways Extrinsic pathway which involves trans-membrane receptor-mediated interaction and by Intrinsic pathway which is a mitochondrial-initiated event.There are Pro-apoptotic genes that lightemupsequences.com support apoptosis like Caspases, TNF, and P53 families, and Anti-apoptotic genes like BCL-2 which stop the programmed cell death leading to cellular proliferation and tumor progression.This study was done to find the role of the anti-apoptotic protein BCL2 in varying histological grades of oral squamous cell carcinoma by immunohistochemistry.